The TUBGCP4 Polyclonal Antibody (PAC055282) is a valuable tool for researchers studying TUBGCP4, a key protein involved in microtubule organization and cell division. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding to the TUBGCP4 protein, this antibody allows for the detection and analysis of TUBGCP4 in a variety of cell types, making it an essential reagent for studies in cell biology and cancer research.TUBGCP4, also known as gamma-tubulin complex protein 4, plays a crucial role in the formation and function of the gamma-tubulin ring complex (γ-TuRC), which is essential for microtubule nucleation and organization.
Dysregulation of TUBGCP4 has been implicated in various cellular processes, including mitotic spindle assembly and chromosome segregation, highlighting its importance in ensuring accurate cell division. Research into TUBGCP4 is vital for understanding the mechanisms underlying these processes and developing targeted therapies for diseases characterized by aberrant cell division, such as cancer.
Western Blot. Positive WB detected in: MCF-7 whole cell lysate. All lanes: TUBGCP4 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 77 kDa. Observed band size: 77 kDa.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO55282 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO55282 at dilution of 1:100.
Background:
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
UniProt Protein Details:
NCBI Summary:
This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
