The TUBGCP4 Polyclonal Antibody (PACO22633) is a valuable tool for researchers investigating the role of TUBGCP4 in cellular processes. TUBGCP4, also known as gamma-tubulin complex protein 4, is involved in microtubule nucleation and organization, playing a key role in cell division and organization.This antibody is raised in rabbits and demonstrates high reactivity with human samples, making it a reliable option for Western blot applications. By binding specifically to the TUBGCP4 protein, researchers can accurately detect and analyze its expression in various cell types, aiding in studies related to cell division, cytoskeleton organization, and tumor growth.
The importance of TUBGCP4 in regulating microtubule dynamics highlights its relevance in cancer research, as dysregulation of microtubule function can contribute to oncogenesis. Additionally, understanding the role of TUBGCP4 in cellular processes can provide insight into potential therapeutic targets for diseases characterized by aberrant cell division, such as cancer.Overall, the TUBGCP4 Polyclonal Antibody (PACO22633) is a valuable tool for researchers looking to delve deeper into the mechanisms underlying cell division and microtubule organization, with potential implications for cancer biology and therapeutic development.
Antibody Name:
TUBGCP4 Antibody (PACO22633)
Antibody SKU:
PACO22633
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human TUBGCP4.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from COLO cells and HT-29 cells, using TUBGCP4 antibody.
Background:
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
UniProt Protein Details:
NCBI Summary:
This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
