The Tubgcp4 Polyclonal Antibody (PACO12989) is a valuable tool for researchers studying Tubgcp4, a key protein involved in centrosome organization and microtubule nucleation. This antibody, produced using rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the Tubgcp4 protein, this antibody enables researchers to detect and analyze Tubgcp4 expression in a variety of cell types, making it a valuable asset for studies in cell biology and cancer research.Tubgcp4 is essential for proper cell division and organization of the microtubule network, making it a crucial player in processes such as mitosis and cell migration.
Dysregulation of Tubgcp4 has been implicated in various diseases, including cancer, making it a promising target for therapeutic interventions. By gaining a deeper understanding of Tubgcp4 function and regulation, researchers can uncover novel insights into cellular processes and potentially develop targeted treatments for diseases involving abnormal cell division.
tubulin, γ complex associated protein 4;TUBGCP4;76P;FLJ14797;GCP4 ;
UniProt Protein Function:
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
UniProt Protein Details:
NCBI Summary:
This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
