The TUBGCP4 Polyclonal Antibody (PACO00844) is a valuable tool for researchers studying TUBGCP4, a protein involved in regulating microtubule dynamics and cell division. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the TUBGCP4 protein, this antibody enables researchers to detect and analyze the protein in various cell types, making it an essential tool for studies in cell biology and cancer research.TUBGCP4, also known as gamma-tubulin complex protein 4, plays a crucial role in organizing and stabilizing microtubule structures during cell division.
Dysregulation of TUBGCP4 has been implicated in cancer development and progression, making it a promising target for therapeutic interventions. By investigating the function of TUBGCP4, researchers can gain insights into the molecular mechanisms underlying cancer and potentially identify new treatment strategies. Unlocking the role of TUBGCP4 in cellular processes may lead to the development of targeted therapies for cancer and other diseases influenced by microtubule dynamics.
Antibody Name:
TUBGCP4 Antibody
Antibody SKU:
PACO00844
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the Internal region of human GCP4.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
UniProt Protein Details:
NCBI Summary:
This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
