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TUBA3E Antibody (PACO36970)

SKU:
PACO36970
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • TUBA3E Antibody PACO36970
  • TUBA3E Antibody PACO36970
€339
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Description

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TUBA3E Antibody (PACO36970)

The TUBA3E Polyclonal Antibody (PAC036970) is a valuable tool for researchers studying TUBA3E, a member of the tubulin superfamily that plays a crucial role in cell division and intracellular transport processes. This antibody, generated in rabbits, exhibits high specificity and reactivity towards human samples, making it ideal for use in various research applications, particularly in immunohistochemistry and immunofluorescence experiments.TUBA3E is a key protein involved in the formation of microtubules, essential structures that are involved in cell shape maintenance, intracellular transport, and chromosome segregation during cell division.

Dysregulation of TUBA3E expression has been linked to various diseases, including cancer and neurodegenerative disorders, highlighting its importance in cellular function and disease pathology.By utilizing the TUBA3E Polyclonal Antibody, researchers can accurately detect and analyze the expression levels and localization of TUBA3E in different cell types and tissues. This antibody's reliability and specificity make it a valuable tool for gaining insights into the functions of TUBA3E in normal cellular processes and disease states, paving the way for potential therapeutic interventions targeting TUBA3E-related pathways.

Antibody Name:TUBA3E Antibody (PACO36970)
Antibody SKU:PACO36970
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Tubulin alpha-3E chain protein (1-250AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot. All lanes: TUBA3E antibody at 3µg/ml. Lane 1: MCF-7 whole cell lysate. Lane 2: Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 50 kDa. Observed band size: 50 kDa.
Product ImageImmunohistochemistry of paraffin-embedded human ovarian cancer using PACO36970 at dilution of 1:100.
Background:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the β chain and one at a non-exchangeable site on the α chain.
Synonyms:Tubulin alpha-3E chain (Alpha-tubulin 3E) [Cleaved into: Detyrosinated tubulin alpha-3E chain], TUBA3E
UniProt Protein Function:TUBA1A: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Expressed at a high level in fetal brain. Belongs to the tubulin family.Protein type: Motility/polarity/chemotaxis; CytoskeletalChromosomal Location of Human Ortholog: 12q13.12Cellular Component: microtubule; recycling endosome; cytoplasmic microtubule; cytosol; nucleusMolecular Function: GTPase activity; protein domain specific binding; protein binding; GTP binding; structural constituent of cytoskeleton; structural molecule activityBiological Process: protein polymerization; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; cell division; organelle organization and biogenesis; cytoskeleton-dependent intracellular transport; mitotic cell cycle; G2/M transition of mitotic cell cycle; microtubule-based processDisease: Lissencephaly 3
UniProt Protein Details:
NCBI Summary:Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, mental retardation, and early-onset epilepsy and caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
UniProt Code:Q6PEY2
NCBI GenInfo Identifier:55977864
NCBI Gene ID:7846
NCBI Accession:Q71U36.1
UniProt Secondary Accession:Q6PEY2,P68363, Q9BQE3, Q13748, Q6PEY2
UniProt Related Accession:Q6PEY2,Q71U36
Molecular Weight:46,297 Da
NCBI Full Name:Tubulin alpha-1A chain
NCBI Synonym Full Names:tubulin, alpha 1a
NCBI Official Symbol:TUBA1A  
NCBI Official Synonym Symbols:LIS3; TUBA3; B-ALPHA-1  
NCBI Protein Information:tubulin alpha-1A chain; hum-a-tub1; hum-a-tub2; tubulin B-alpha-1; tubulin alpha-3 chain; tubulin, alpha, brain-specific
UniProt Protein Name:Tubulin alpha-1A chain
UniProt Synonym Protein Names:Alpha-tubulin 3; Tubulin B-alpha-1; Tubulin alpha-3 chain
Protein Family:
UniProt Gene Name:TUBA1A  
UniProt Entry Name:TBA1A_HUMAN
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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