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TUBA1A/TUBA1B Antibody (PACO07151)

SKU:
PACO07151
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • TUBA1A/TUBA1B Antibody PACO07151
  • TUBA1A/TUBA1B Antibody PACO07151
  • TUBA1A/TUBA1B Antibody PACO07151
€269
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Description

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TUBA1A/TUBA1B Antibody (PACO07151)

The TUBA1A/TUBA1B Polyclonal Antibody (PACO07151) is a vital tool for researchers studying the functions of TUBA1A and TUBA1B proteins. These proteins are crucial components of the microtubule network, playing essential roles in cell division, intracellular transport, and cell shape maintenance. The antibody, generated in rabbits, exhibits high reactivity towards human samples and is validated for use in Western blot applications.By specifically binding to the TUBA1A and TUBA1B proteins, this antibody enables accurate detection and analysis of these key components in various cell types.

Its versatility makes it suitable for investigations in cell biology, developmental biology, and neurology. Understanding the functions of TUBA1A and TUBA1B is essential for unraveling their roles in cellular processes and human diseases such as cancer, neurodegenerative disorders, and developmental abnormalities. Researchers can leverage this antibody to gain insights into the mechanisms underlying these conditions and develop potential therapeutic strategies.

Antibody Name:TUBA1A/TUBA1B Antibody (PACO07151)
Antibody SKU:PACO07151
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:ELISA:1:5000, WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse, Rat
Immunogen:Synthesized peptide derived from the C-terminal region of human Tubulin α .
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern Blot analysis of Hela A549 cells using Tubulin alpha Polyclonal Antibody.
Product ImageWestern Blot analysis of HELA HEPG2 using Tubulin alpha Polyclonal Antibody.
Product ImageWestern Blot analysis of HepG2 cells using Tubulin alpha Polyclonal Antibody.
Synonyms:TUBA1A; TUBA3; Tubulin α-1A chain; α-tubulin 3; Tubulin B-α-1; Tubulin α-3 chain; TUBA1B; Tubulin α-1B chain; α-tubulin ubiquitous; Tubulin K-α-1; Tubulin α-ubiquitous chain
UniProt Protein Function:TUBA1A: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Expressed at a high level in fetal brain. Belongs to the tubulin family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 12q13.12

Cellular Component: microtubule; recycling endosome; cytoplasmic microtubule; cytosol; nucleus

Molecular Function:GTPase activity; protein domain specific binding; protein binding; GTP binding; structural constituent of cytoskeleton; structural molecule activity

Biological Process: protein polymerization; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; cell division; organelle organization and biogenesis; cytoskeleton-dependent intracellular transport; mitotic cell cycle; G2/M transition of mitotic cell cycle; microtubule-based process

Disease: Lissencephaly 3

NCBI Summary:Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blot studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, intellectual disability, and early-onset epilepsy caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
UniProt Code:Q71U36
NCBI GenInfo Identifier:55977864
NCBI Gene ID:7846
NCBI Accession:Q71U36.1
UniProt Secondary Accession:Q71U36,P68363,
UniProt Related Accession:Q71U36
Molecular Weight:~ 55kDa
NCBI Full Name:Tubulin alpha-1A chain
NCBI Synonym Full Names:tubulin alpha 1a
NCBI Official Symbol:TUBA1A  
NCBI Official Synonym Symbols:LIS3; TUBA3; B-ALPHA-1  
NCBI Protein Information:tubulin alpha-1A chain
UniProt Protein Name:Tubulin alpha-1A chain
UniProt Synonym Protein Names:Alpha-tubulin 3; Tubulin B-alpha-1; Tubulin alpha-3 chain
Protein Family:Tubulin
UniProt Gene Name:TUBA1A  
UniProt Entry Name:TBA1A_HUMAN
AntibodiesELISA Kits
TUBA1A/TUBA1B Antibody (PACO00086)Tubulin alpha Colorimetric Cell-Based ELISA Kit
TUBA1A/TUBA1B Antibody (PACO01770)
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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