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Anti-TUBA1A Antibody (MACO0009)

SKU:
MACO0009
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Mouse
Isotype:
IgG
Applications:
ELISA
WB
IP
Antibody Type:
Monoclonal Antibody
Conjugation:
Unconjugated
  • Anti-TUBA1A Antibody MACO0009
  • Anti-TUBA1A Antibody MACO0009
€319

Description

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Anti-TUBA1A Antibody (MACO0009)

The TUBA1A Monoclonal Antibody (MACO0009) is a valuable tool for research involving the TUBA1A protein, which is a member of the alpha tubulin family that plays a crucial role in microtubule structure and function. This antibody, developed using advanced monoclonal antibody technology, is highly specific for detecting TUBA1A in human samples and is suitable for use in various research applications, including Western blot and immunohistochemistry.TUBA1A is essential for cell division, intracellular transport, and cell morphology, making it a key target for studying cellular processes and diseases such as cancer and neurodevelopmental disorders.

By using the TUBA1A Monoclonal Antibody, researchers can gain insights into the function and regulation of TUBA1A in different cell types and tissues, advancing our understanding of microtubule dynamics and its implications in various physiological and pathological conditions.

Product Name:Anti-TUBA1A Antibody
Product Sku:MACO0009
Size:50ug
Host Species:Mouse
Tested Applications:ELISA, WB, IP
Recommended Dilutions:WB:1:500-1:5000, IP:1:200-1:2000
Species Reactivity:Human,Mouse,Rat
Immunogen:Recombinant Protein
Form:Liquid
Storage Buffer:PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method:The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Clonality:Monoclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:
Synonyms:Tubulin alpha-1A chain
Product ImageWestern blot analysis of 1) Hela, 2) Rat BrianTissue, 3) Mouse Brain Tissue, diluted at 1:5000.
Product Image1) Input: Mouse Brain Tissue Lysate 2) IP product: IP dilute 1:200
UniProt Protein Function:TUBA1A: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Expressed at a high level in fetal brain. Belongs to the tubulin family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 12q13.12

Cellular Component: microtubule; recycling endosome; cytoplasmic microtubule; cytosol; nucleus

Molecular Function:GTPase activity; protein domain specific binding; protein binding; GTP binding; structural constituent of cytoskeleton; structural molecule activity

Biological Process: protein polymerization; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; cell division; organelle organization and biogenesis; cytoskeleton-dependent intracellular transport; mitotic cell cycle; G2/M transition of mitotic cell cycle; microtubule-based process

Disease: Lissencephaly 3

NCBI Summary:Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blot studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, intellectual disability, and early-onset epilepsy caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
UniProt Code:Q71U36
NCBI GenInfo Identifier:55977864
NCBI Gene ID:7846
NCBI Accession:Q71U36.1
UniProt Secondary Accession:Q71U36,P68363,
UniProt Related Accession:Q71U36
Molecular Weight:~ 55kDa
NCBI Full Name:Tubulin alpha-1A chain
NCBI Synonym Full Names:tubulin alpha 1a
NCBI Official Symbol:TUBA1A  
NCBI Official Synonym Symbols:LIS3; TUBA3; B-ALPHA-1  
NCBI Protein Information:tubulin alpha-1A chain
UniProt Protein Name:Tubulin alpha-1A chain
UniProt Synonym Protein Names:Alpha-tubulin 3; Tubulin B-alpha-1; Tubulin alpha-3 chain
Protein Family:Tubulin
UniProt Gene Name:TUBA1A  
UniProt Entry Name:TBA1A_HUMAN

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