TTR Rabbit Monoclonal Antibody (CAB4067)
- SKU:
- CAB4067
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
Product Name: | TTR Rabbit Monoclonal Antibody |
SKU: | CAB4067 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 68-147 of human TTR (P02766). |
Sequence: | KTSE SGEL HGLT TEEE FVEG IYKV EIDT KSYW KALG ISPF HEHA EVVF TAND SGPR RYTI AALL SPYS YSTT AVVT NPKE |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CTS; TTN; ATTR; CTS1; PALB; TBPA; HEL111; HsT2651; TTR |
Positive Sample: | Human plasma,Mouse kidney,Mouse pancreas |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Secreted. |
Calculated MW: | 16kDa |
Observed MW: | 16kDa/30kDa |
This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome.
Purification Method: | Affinity purification |
Gene ID: | 7276 |
Clone Number: | ARC0892 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |