The TTR Rabbit Monoclonal Antibody (CAB4067) is a cutting-edge tool for researchers studying Transthyretin (TTR), a protein primarily produced by the liver and involved in the transport of thyroid hormones and retinol (vitamin A). This antibody, developed using advanced rabbit monoclonal technology, demonstrates high specificity and sensitivity for detecting TTR in human samples.TTR is a biomarker for various diseases, including familial amyloid polyneuropathy (FAP) and senile systemic amyloidosis. The TTR Rabbit Monoclonal Antibody is optimized for use in immunohistochemistry, immunofluorescence, and other research applications, providing researchers with a reliable tool for investigating TTR expression and distribution in tissue samples.
By using the TTR Rabbit Monoclonal Antibody, researchers can gain valuable insights into the role of TTR in disease pathogenesis and progression. This antibody's high affinity for TTR ensures accurate and reproducible results, making it ideal for studies in neurology, cardiology, and other fields where TTR abnormalities are implicated. Unlock the potential of your research with the TTR Rabbit Monoclonal Antibody (CAB4067).
Product Name:
TTR Rabbit Monoclonal Antibody
SKU:
CAB4067
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 68-147 of human TTR (P02766).
This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome.
Purification Method:
Affinity purification
Gene ID:
7276
Clone Number:
ARC0892
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of Human plasma, using TTR Rabbit mAb (CAB4067) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
