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TTR Rabbit Polyclonal Antibody (CAB1120)

SKU:
CAB1120
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
  • Signal Transduction Antibodies 1 Anti-TTR Antibody CAB1120
  • Signal Transduction Antibodies 1 Anti-TTR Antibody CAB1120
  • Signal Transduction Antibodies 1 Anti-TTR Antibody CAB1120
€139 - €419
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Description

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TTR Rabbit Polyclonal Antibody (CAB1120)

The Transthyretin Polyclonal Antibody (CAB1120) is a valuable tool for researchers studying Transthyretin (TTR), a protein primarily produced in the liver and involved in transporting thyroid hormones and Vitamin A. This antibody, generated in rabbits, is highly specific to human samples and is validated for use in various applications, including Western blot and immunohistochemistry.Transthyretin is known for its role in binding and transporting thyroxine and retinol-binding protein in the blood and cerebrospinal fluid. Dysregulation of TTR has been implicated in various diseases, including amyloidosis, neurodegenerative disorders, and familial amyloidotic polyneuropathy.

By using this polyclonal antibody to detect and analyze TTR expression in different tissues and cell types, researchers can gain valuable insights into the function and potential therapeutic implications of this important protein.Understanding the expression and localization of Transthyretin is crucial for advancing research in areas such as neurology, metabolism, and protein folding disorders. The Transthyretin Polyclonal Antibody (CAB1120) provides a reliable tool for investigating TTR biology and its role in disease pathology and therapeutic development.

Product Name:TTR Rabbit Polyclonal Antibody
SKU:CAB1120
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-147 of human TTR (NP_000362.1).
Sequence:GPTG TGES KCPL MVKV LDAV RGSP AINV AVHV FRKA ADDT WEPF ASGK TSES GELH GLTT EEEF VEGI YKVE IDTK SYWK ALGI SPFH EHAE VVFT ANDS GPRR YTIA ALLS PYSY STTA VVTN PKE
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:100 IF/ICC,1:50 - 1:100
Synonyms:CTS; TTN; ATTR; CTS1; PALB; TBPA; HEL111; HsT2651; TTR
Positive Sample:HepG2,Rat liver,Rat brain
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Secreted.
Calculated MW:16kDa

This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome.

Purification Method:Affinity purification
Gene ID:7276
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from HepG2 cells, using TTR Rabbit pAb (CAB1120) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.

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