The TTL5 Polyclonal Antibody (PAC036350) is a valuable tool for researchers investigating the TTL5 protein, a crucial regulator of microtubule dynamics and cell division. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it ideal for Western blot applications. By binding to the TTL5 protein, this antibody enables the detection and analysis of TTL5 expression in various cell types, offering insights into its role in cellular processes.TTL5, a member of the tubulin tyrosine ligase-like protein family, is essential for the proper functioning of the microtubule cytoskeleton, which is involved in cell shape, motility, and intracellular transport.
Dysregulation of TTL5 has been implicated in various diseases, including cancer and neurological disorders, highlighting its potential as a therapeutic target. Research on TTL5 is crucial for advancing our understanding of these conditions and developing novel treatments to address them.
Antibody Name:
TTLL5 Antibody (PACO36350)
Antibody SKU:
PACO36350
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human Tubulin polyglutamylase TTLL5 protein (1-269AA)
Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction.
Synonyms:
Tubulin polyglutamylase TTLL5 (EC 6.-.-.-) (SRC1 and TIF2-associated modulatory protein) (Tubulin--tyrosine ligase-like protein 5), TTLL5, KIAA0998 STAMP
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009]
