The TTLL2 Polyclonal Antibody (PAC040502) is a valuable tool for researchers studying TTLL2, a protein involved in the process of protein polyglutamylation. This antibody, produced in rabbits, is highly specific to human TTLL2 and has been validated for use in Western blot applications. By targeting the TTLL2 protein, this antibody allows for the detection and analysis of TTLL2 expression in various cell types, making it ideal for research in cell biology and neurobiology.TTLL2 is known to play a crucial role in the modification of tubulin proteins, which are essential for the structure and function of microtubules in cells.
Dysregulation of TTLL2 activity has been linked to neurodevelopmental disorders and cancer, making it a promising target for therapeutic interventions. By studying the function of TTLL2 using this antibody, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially uncover new treatment strategies.
Antibody Name:
TTLL2 Antibody (PACO40502)
Antibody SKU:
PACO40502
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Probable tubulin polyglutamylase TTLL2 protein (401-592AA)
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO40502 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO40502 at dilution of 1:100.
Background:
Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins.
Synonyms:
Probable tubulin polyglutamylase TTLL2 (EC 6) (Testis-specific protein NYD-TSPG) (Tubulin--tyrosine ligase-like protein 2), TTLL2, C6orf104
UniProt Protein Function:
TTLL2: Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins. Belongs to the tubulin--tyrosine ligase family.Protein type: EC 6.-.-.-; LigaseChromosomal Location of Human Ortholog: 6q27Molecular Function: ATP binding; ligase activityBiological Process: protein modification process
