The TTI2 Polyclonal Antibody (PACO60176) is a cutting-edge research tool designed for studying TTI2, a protein involved in various cellular processes. This high-quality antibody is raised in rabbits and exhibits strong reactivity with human samples, making it an ideal choice for Western blot applications. By specifically binding to TTI2, researchers can detect and analyze this protein in a variety of cell types, providing valuable insights into its function and role in different biological pathways.TTI2, also known as Tel2-interacting protein 2, is a key player in cellular processes such as telomere maintenance and DNA damage response. Its involvement in these critical pathways underscores its importance in maintaining genomic stability and cell viability.
Research into TTI2 may shed light on its potential implications in diseases such as cancer and age-related disorders, offering new avenues for therapeutic interventions targeting these conditions.By utilizing the TTI2 Polyclonal Antibody (PACO60176), researchers can delve deeper into the mechanisms underlying TTI2 function, paving the way for advancements in biomedical research and drug development. This antibody serves as a valuable tool for investigators seeking to unravel the complexities of TTI2 biology and its impact on human health.
Western Blot. Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, PC-3 whole cell lysate, Rat kidney tissue. All lanes: TTI2 antibody at 8.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 57 kDa. Observed band size: 57 kDa.
IHC image of PACO60176 diluted at 1:100 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of PACO60176 diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs.
Synonyms:
TELO2-interacting protein 2, TTI2, C8orf41
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT) which also includes telomere length regulation protein and TELO2 interacting protein 1. The TTT complex is involved in cellular resistance to DNA damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance. [provided by RefSeq, May 2013]
