The TTI1 Antibody (PAC047494) is a valuable tool for researchers studying the TTI1 protein, which plays a crucial role in protein folding and cell cycle regulation. This polyclonal antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the TTI1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for research in molecular biology and cell signaling pathways.TTI1 is known for its involvement in the TTT complex, which is essential for proper protein folding and function in the cell.
Dysfunction of TTI1 has been associated with various diseases, including neurodegenerative disorders and cancer. By understanding the role of TTI1 in these pathways, researchers can uncover potential therapeutic targets for treating these diseases and improving patient outcomes.Overall, the TTI1 Antibody (PAC047494) is a powerful tool for researchers looking to delve deeper into the functions of the TTI1 protein and its implications for disease pathology. Its specificity and reliability make it a valuable asset in the fields of molecular biology, cell biology, and biomedicine.
Immunohistochemistry of paraffin-embedded human heart tissue using PACO47494 at dilution of 1:100.
Immunofluorescent analysis of Hela cells using PACO47494 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO47494 at dilution of 1:100.
Background:
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
Synonyms:
TELO2-interacting protein 1 homolog (Protein SMG10), TTI1, KIAA0406 SMG10
UniProt Protein Function:
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
