The TTI1 Antibody (PAC020787) is a high-quality polyclonal antibody designed for research involving the TTI1 protein, which is involved in various cellular processes, including DNA repair and cell cycle regulation. This antibody is raised in rabbits and has been extensively validated for use in Western blot and immunohistochemistry applications. It specifically binds to the TTI1 protein, allowing for accurate detection and analysis in different cell types.TTI1 is a key player in the DNA damage response pathway and is essential for maintaining genomic stability. Dysregulation of TTI1 has been implicated in various diseases, including cancer and neurodegenerative disorders.
By studying the function of TTI1, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.Overall, the TTI1 Antibody is a valuable tool for researchers interested in exploring the role of TTI1 in cellular processes and disease pathology. Its high specificity and sensitivity make it ideal for use in a wide range of research applications, particularly in the fields of molecular biology, oncology, and neurology.
Antibody Name:
TTI1 Antibody (PACO20787)
Antibody SKU:
PACO20787
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:30-1:150
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human TTI1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20787(TTI1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20787(TTI1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
Synonyms:
TELO2 interacting protein 1
UniProt Protein Function:
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
