The TTI1 Antibody (PAC020786) is a valuable tool for researchers studying the TTI1 protein, which is involved in telomere maintenance and cell cycle regulation. This polyclonal antibody, produced specifically for human samples, is highly reactive and suitable for Western blot applications.TTI1, a key component of the TTT complex, plays a critical role in maintaining telomere length and integrity, which is essential for genome stability and cell proliferation. Dysregulation of TTI1 has been implicated in various diseases, including cancer, highlighting its importance in cellular function.
By binding specifically to TTI1, this antibody enables the detection and analysis of the protein in a variety of cell types, making it an ideal tool for research in molecular biology, cancer biology, and cell signaling pathways. Understanding the function of TTI1 is crucial for developing targeted therapies aimed at modulating telomere maintenance and cell cycle progression in disease states.
Antibody Name:
TTI1 Antibody (PACO20786)
Antibody SKU:
PACO20786
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human TTI1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20786(TTI1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20786(TTI1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
Synonyms:
TELO2 interacting protein 1
UniProt Protein Function:
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
