The TTF1 Monoclonal Antibody is a versatile tool for researchers studying thyroid transcription factor 1 (TTF1), a critical transcription factor involved in lung and thyroid development. This antibody, derived from mouse monoclonal cells, boasts high specificity and sensitivity for detecting TTF1 in a variety of samples, including human tissues and cell lines.TTF1 plays a crucial role in regulating gene expression in the lungs and thyroid, making it a key player in respiratory and thyroid diseases. By using the TTF1 Monoclonal Antibody, researchers can accurately quantify and analyze TTF1 expression levels in different experimental conditions, shedding light on its function and potential as a therapeutic target.
With its ability to specifically bind to TTF1, this antibody is an essential tool for investigations in lung and thyroid biology, aiding in the study of diseases such as lung cancer, thyroid cancer, and respiratory disorders. Its reliability in Western blot applications and immunohistochemistry make it a valuable asset for researchers seeking to explore the intricacies of TTF1 function and regulation.
This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription.
Purification Method:
Affinity purification
Gene ID:
7080
Clone Number:
ARC2744
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded Human lung adenocarcinoma using NKX2-1 Rabbit mAb (CAB22248) at dilution of 1:100 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
