The TTC30B Polyclonal Antibody (PACO37930) is a valuable tool for researchers studying TTC30B, a protein involved in ciliogenesis and cilia-related processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the TTC30B protein, this antibody enables detection and analysis in a variety of cell types, making it perfect for studies in developmental biology and gene regulation.TTC30B is essential for the formation and function of cilia, which are hair-like structures on the surface of cells involved in cell signaling and movement.
Dysregulation of cilia formation has been linked to a range of genetic disorders and diseases, making TTC30B a key molecule of interest in research on ciliopathies and related conditions. Investigating the role of TTC30B is crucial for understanding the mechanisms that govern cilia formation and function, with potential implications for therapeutic developments targeting cilia-related disorders.
Western blot. All lanes: TTC30B antibody at 5µg/ml. Lane 1: MDA-MB-231 whole cell lysate. Lane 2: U251 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 77 kDa. Observed band size: 77 kDa.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO37930 at dilution of 1:100.
Background:
Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
Synonyms:
Tetratricopeptide repeat protein 30B (TPR repeat protein 30B), TTC30B
UniProt Protein Function:
TTC30B: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. Belongs to the TTC30/dfy-1/fleer family.Chromosomal Location of Human Ortholog: 2q31.2Cellular Component: ciliumMolecular Function: protein bindingBiological Process: cilium biogenesis; intraflagellar transport
