The TTC23 Polyclonal Antibody (PAC017332) is a valuable tool for researchers studying the TTC23 protein, which is involved in various cellular processes, including ciliogenesis and cell cycle regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for use in Western blot applications. By binding to the TTC23 protein, this antibody enables the detection and analysis of TTC23 expression in different cell types, facilitating research in the fields of cell biology and genetics.
TTC23, a critical component in the formation and function of cilia, plays a crucial role in cellular signaling and development. Dysregulation of TTC23 has been linked to various genetic disorders and ciliopathies, making it a target of interest in the study of cilia-related diseases. By understanding the mechanisms by which TTC23 functions, researchers can gain insights into its role in disease pathogenesis and potentially identify novel therapeutic targets for these conditions.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17332(TTC23 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse adrenal gland and kidney tissue, Primary antibody: PACO17332(TTC23 Antibody) at dilution 1/400 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO17332(TTC23 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The tetratricopeptide repeat (TPR) is a structural motif. It consists in a degenerate 34 amino acid, sequence motif identified in a wide variety of proteins. It is found in tandem arrays of 3–16 motifs,[1] which form scaffolds to mediate protein–protein interactions and often the assembly of multiprotein complexes. These repeats usually fold together to produce a single, linearsolenoid domain called TPR domain.
Synonyms:
tetratricopeptide repeat domain 23
UniProt Protein Function:
TTC23: 3 isoforms of the human protein are produced by alternative splicing.
