The TTC23 Polyclonal Antibody (PAC017331) is a valuable tool for researchers studying TTC23, a protein involved in ciliary function and microtubule organization. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the TTC23 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an excellent choice for studies focused on cilia biology and cellular transport processes.TTC23 is essential for normal ciliary function, playing a crucial role in maintaining the structure and function of cilia, which are critical for cellular signaling and sensory processes.
Dysregulation of TTC23 has been linked to ciliopathies, genetic disorders characterized by defects in cilia structure and function. Research into TTC23 is important for understanding the mechanisms underlying ciliary dysfunction and could potentially lead to novel therapeutic approaches for ciliopathy-related diseases. With its specificity and reliability in detecting TTC23, the PAC017331 antibody is a valuable asset for researchers investigating cilia-related biology and seeking to uncover the role of TTC23 in human health and disease.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17331(TTC23 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The tetratricopeptide repeat (TPR) is a structural motif. It consists in a degenerate 34 amino acid, sequence motif identified in a wide variety of proteins. It is found in tandem arrays of 3–16 motifs,[1] which form scaffolds to mediate protein–protein interactions and often the assembly of multiprotein complexes. These repeats usually fold together to produce a single, linearsolenoid domain called TPR domain.
Synonyms:
tetratricopeptide repeat domain 23
UniProt Protein Function:
TTC23: 3 isoforms of the human protein are produced by alternative splicing.
