The TSR2 Polyclonal Antibody (PAC012967) is a valuable tool for researchers studying TSR2, a protein involved in mRNA splicing and ribosome biogenesis. This antibody, raised in rabbits, has high reactivity with human samples and is suitable for use in Western blot applications. By binding specifically to TSR2, this antibody allows for the detection and analysis of TSR2 expression in various cell types, making it ideal for studies in molecular biology and cell biology.TSR2 is known to play a crucial role in the regulation of gene expression and protein synthesis, making it a key player in the maintenance of cellular homeostasis.
Dysregulation of TSR2 has been implicated in various diseases, including cancer and genetic disorders, making it a promising target for therapeutic intervention. By elucidating the function of TSR2, researchers can gain insights into the molecular mechanisms underlying these diseases and potentially develop novel treatment strategies.
TSR2, 20S rRNA accumulation, homolog (S. cerevisiae);TSR2;DT1P1A10;MGC20451;WGG1 ;
UniProt Protein Function:
TSR2: May be involved in 20S pre-rRNA processing (Potential). Belongs to the TSR2 family.Chromosomal Location of Human Ortholog: Xp11.22Cellular Component: nucleusMolecular Function: protein bindingBiological Process: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)Disease: Diamond-blackfan Anemia 14 With Mandibulofacial Dysostosis
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene appears to repress the transcription of NF-kappaB and may be involved in apoptosis. Defects in this gene are a cause of Diamond-Blackfan anemia. [provided by RefSeq, Oct 2016]
