The TSPO Polyclonal Antibody (CAB15649) is a valuable tool for researchers studying the Translocator Protein (TSPO), a key player in neuroinflammation and mitochondrial function. This antibody, generated in rabbits, is highly specific for TSPO and has been validated for use in various applications, including Western blot and immunofluorescence.TSPO is a transmembrane protein found in the outer mitochondrial membrane and is involved in a wide range of physiological processes, including steroidogenesis, apoptosis, and immune response regulation. Its overexpression has been linked to neuroinflammatory diseases, making it a potential target for therapeutic interventions.
The TSPO Polyclonal Antibody allows for the precise detection and analysis of TSPO levels in different cell types, which is essential for understanding its role in disease pathogenesis.Researchers in neuroscience, neurology, and immunology can benefit from using the TSPO Polyclonal Antibody to elucidate the molecular mechanisms underlying neuroinflammation and mitochondrial dysfunction. By studying TSPO expression and activity, scientists can uncover new insights into the pathophysiology of neuroinflammatory disorders and develop novel treatment strategies targeting TSPO.
Product Name:
PBR/TSPO Rabbit Polyclonal Antibody
SKU:
CAB15649
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-50 of human PBR/PBR/TSPO (NP_000705.2).
Sequence:
MAPP WVPA MGFT LAPS LGCF VGSR FVHG EGLR WYAG LQKP SWHP PHWV LG
Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein.
Purification Method:
Affinity purification
Gene ID:
706
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using PBR/TSPO Rabbit pAb (CAB15649) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
