The Tspear Antibody (PAC061434) is a specific polyclonal antibody designed for research involving TSPEAR, a transcription factor involved in gene regulation. The antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications including Western blot and immunofluorescence. It binds specifically to the TSPEAR protein, allowing for the detection and analysis of TSPEAR expression in different cell types, making it an ideal tool for studies in genetics, molecular biology, and developmental biology.
TSPEAR is known to play a critical role in gene regulation and cellular differentiation, making it a key target for research in various biological processes. Its involvement in transcriptional regulation suggests its potential significance in various diseases and developmental disorders. Understanding the function of TSPEAR is essential for unraveling its role in gene expression and cellular function, and for developing potential therapeutic strategies targeting TSPEAR in disease contexts.
Antibody Name:
TSPEAR Antibody (PACO61434)
Antibody SKU:
PACO61434
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Human
Immunogen:
Recombinant Human Thrombospondin-type laminin G domain and EAR repeat-containing protein (248-433AA)
Western Blot. Positive WB detected in: Raji whole cell lysate. All lanes: TSPEAR antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 75, 67 kDa. Observed band size: 75 kDa.
Background:
May play a role in development or function of the auditory system.
Synonyms:
Thrombospondin-type laminin G domain and EAR repeat-containing protein, TSP-EAR, TSPEAR, C21orf29
UniProt Protein Function:
TSPEAR: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 21q22.3Cellular Component: cell surface; stereociliumBiological Process: sensory perception of soundDisease: Deafness, Autosomal Recessive 98
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein that contains a N-terminal thrombospondin-type laminin G domain and several tandem arranged epilepsy-associated repeats (EARs). A mutation in this gene is the cause of autosomal recessive deafness-98. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
