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TSPAN12 Antibody (PACO12958)

SKU:
PACO12958
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
Frequently bought together:

Description

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TSPAN12 Antibody (PACO12958)

The TSPAN12 Polyclonal Antibody (PAC012958) is a valuable tool for research involving TSPAN12, a member of the tetraspanin family of proteins known to be involved in cell adhesion, migration, and signaling. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the TSPAN12 protein, this antibody allows for the detection and analysis of TSPAN12 in various cell types, making it an ideal choice for studies in developmental biology, angiogenesis, and cancer research.

TSPAN12 has been shown to play a critical role in angiogenesis, a process essential for the formation of new blood vessels and tumor growth. Its involvement in promoting cell migration and invasion makes it a potential target for research into cancer metastasis and tumor progression. Understanding the function of TSPAN12 can provide valuable insights into the mechanisms underlying these processes and may lead to the development of novel therapeutic strategies targeting angiogenesis and cancer.

Antibody Name:TSPAN12 Antibody (PACO12958)
Antibody SKU:PACO12958
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human TSPAN12
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:tetraspanin 12;TSPAN12;NET-2;TM4SF12 ;
UniProt Protein Function:TSPAN12: a multi-pass membrane protein. Member of the transmembrane 4 superfamily, also known as the tetraspanin family. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity. Defects in TSPAN12 are the cause of vitreoretinopathy exudative type 5 (EVR5). It is a disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. Twp isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 7q31.31

Cellular Component: membrane; integral to plasma membrane; integral to membrane

Molecular Function:Wnt receptor activity

Biological Process: cell surface receptor linked signal transduction; angiogenesis; regulation of angiogenesis

Disease: Exudative Vitreoretinopathy 5

UniProt Code:O95859
NCBI GenInfo Identifier:11135167
NCBI Gene ID:
NCBI Accession:O95859.1
Molecular Weight:Observed MW: 35kDa
NCBI Full Name:Tetraspanin-12
UniProt Protein Name:Tetraspanin-12
UniProt Synonym Protein Names:Tetraspan NET-2; Transmembrane 4 superfamily member 12
UniProt Gene Name:TSPAN12  
UniProt Entry Name:TSN12_HUMAN

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