The TSEN54 Polyclonal Antibody (CAB15227) is a versatile tool for researchers working in the field of RNA splicing. This antibody, produced in rabbits, is specifically designed to target the TSEN54 protein, an essential component of the tRNA splicing endonuclease complex.TSEN54 plays a crucial role in the processing of precursor tRNAs, ensuring accurate splicing and maturation of these essential molecules. By targeting TSEN54, researchers can investigate the mechanisms underlying RNA splicing and its impact on gene expression and cellular function.The TSEN54 Polyclonal Antibody is highly reactive with human samples and has been validated for use in Western blot applications.
Its ability to specifically bind to the TSEN54 protein enables precise detection and analysis in a variety of cell types, making it an ideal tool for studies in RNA biology, gene regulation, and related fields.Research into RNA processing and splicing is essential for understanding fundamental cellular processes and the development of therapies targeting diseases associated with dysfunctional RNA metabolism. By using the TSEN54 Polyclonal Antibody, researchers can advance our knowledge of RNA splicing mechanisms and potentially uncover new therapeutic targets for a range of genetic disorders and cancers.
Product Name:
TSEN54 Rabbit Polyclonal Antibody
SKU:
CAB15227
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human TSEN54 (NP_997229.2).
This gene encodes a subunit of the tRNA splicing endonuclease complex, which catalyzes the removal of introns from precursor tRNAs. The complex is also implicated in pre-mRNA 3-prime end processing. Mutations in this gene result in pontocerebellar hypoplasia type 2.
Purification Method:
Affinity purification
Gene ID:
283989
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TSEN54 Rabbit pAb (CAB15227) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
