The TSEN2 Polyclonal Antibody (CAB7838) is a powerful tool for researchers studying TSEN2, a key protein involved in tRNA splicing. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the TSEN2 protein, this antibody enables accurate detection and analysis in various cell types, making it an essential component for studies in molecular biology and RNA processing.TSEN2 is a critical enzyme in the splicing of transfer RNA molecules, which are essential for protein synthesis in cells.
Dysregulation of tRNA splicing has been linked to various human diseases, making TSEN2 a promising target for research into conditions such as neurodegenerative disorders and cancer. By elucidating the function of TSEN2, researchers can gain insights into the molecular mechanisms underlying these diseases and potentially identify new therapeutic strategies.
Product Name:
TSEN2 Rabbit Polyclonal Antibody
SKU:
CAB7838
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human TSEN2 (NP_079541.1).
This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
80746
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TSEN2 antibody (CAB7838) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
