The TSC2 Rabbit Monoclonal Antibody (CAB19540) is a valuable tool for researchers studying TSC2, a tumor suppressor protein involved in the regulation of cell growth and proliferation. This antibody, raised in rabbits, has high specificity and affinity for TSC2 in human samples, making it suitable for applications such as Western blot and immunohistochemistry.TSC2 is a key player in the mTOR signaling pathway, which controls cell growth and metabolism in response to various signals. Dysregulation of this pathway is linked to various diseases, including cancer and metabolic disorders.
The TSC2 antibody enables the detection and analysis of TSC2 protein levels in different cell types, providing insights into its function and potential therapeutic targeting.By investigating the role of TSC2 in cellular processes, researchers can gain a better understanding of its impact on disease pathology and identify novel treatment strategies. The TSC2 Rabbit Monoclonal Antibody offers reliable performance and reproducible results, making it a valuable asset for studies in cancer research, cell biology, and drug development.
Product Name:
TSC2 Rabbit Monoclonal Antibody
SKU:
CAB19540
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1700-1807 of human Tuberin (P49815).
WB,1:500 - 1:1000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
LAM; TSC4; PPP1R160; TSC2
Positive Sample:
PC-3,293T
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Membrane, Peripheral membrane protein.
Calculated MW:
201kDa
Observed MW:
200kDa
This gene is a tumor suppressor gene that encodes the growth inhibitory protein tuberin. Tuberin interacts with hamartin to form the TSC protein complex which functions in the control of cell growth. This TSC protein complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signaling which is a major regulator of anabolic cell growth. Mutations in this gene have been associated with tuberous sclerosis and lymphangioleiomyomatosis.
Purification Method:
Affinity purification
Gene ID:
7249
Clone Number:
ARC0019
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using TSC2 Rabbit mAb (CAB19540) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
