TSC2 Rabbit Monoclonal Antibody (CAB19540)
- SKU:
- CAB19540
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | TSC2 Rabbit Monoclonal Antibody |
SKU: | CAB19540 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1700-1807 of human Tuberin (P49815). |
Sequence: | AKIV SDRN LPFV ARQM ALHA NMAS QVHH SRSN PTDI YPSK WIAR LRHI KRLR QRIC EEAA YSNP SLPL VHPP SHSK APAQ TPAE PTPG YEVG QRKR LISS VEDF TEFV |
Tested Applications: | WB IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | LAM; TSC4; PPP1R160; TSC2 |
Positive Sample: | PC-3,293T |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Membrane, Peripheral membrane protein. |
Calculated MW: | 201kDa |
Observed MW: | 200kDa |
This gene is a tumor suppressor gene that encodes the growth inhibitory protein tuberin. Tuberin interacts with hamartin to form the TSC protein complex which functions in the control of cell growth. This TSC protein complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signaling which is a major regulator of anabolic cell growth. Mutations in this gene have been associated with tuberous sclerosis and lymphangioleiomyomatosis.
Purification Method: | Affinity purification |
Gene ID: | 7249 |
Clone Number: | ARC0019 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |