The TSC2 Polyclonal Antibody (CAB16007) is a valuable tool for research involving TSC2, a tumor suppressor protein implicated in the regulation of cell growth and proliferation. This antibody, produced using rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the TSC2 protein, it allows for the detection and analysis of TSC2 in various cell types, making it ideal for studies in cancer research and cell biology.TSC2, also known as tuberin, is a critical player in the mTOR signaling pathway, which regulates cell growth and metabolism.
Dysregulation of TSC2 has been linked to the development of tumors and conditions such as tuberous sclerosis complex. Investigating the function and regulation of TSC2 is essential for understanding its role in cancer progression and for developing targeted therapies.Overall, the TSC2 Polyclonal Antibody is a valuable tool for researchers studying the role of TSC2 in cancer biology and cell signaling pathways. Its high specificity and sensitivity make it a reliable reagent for Western blot analysis and other experimental techniques.
Product Name:
TSC2 Rabbit Polyclonal Antibody
SKU:
CAB16007
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1531-1807 of TSC2 (NP_000539.2).
This gene is a tumor suppressor gene that encodes the growth inhibitory protein tuberin. Tuberin interacts with hamartin to form the TSC protein complex which functions in the control of cell growth. This TSC protein complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signaling which is a major regulator of anabolic cell growth. Mutations in this gene have been associated with tuberous sclerosis and lymphangioleiomyomatosis.
Purification Method:
Affinity purification
Gene ID:
7249
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunofluorescence analysis of C6 cells using TSC2 Rabbit pAb (CAB16007) at dilution of 1:100. Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
