The TSC2 Polyclonal Antibody (CAB0492) is a valuable tool for researchers studying TSC2, a protein associated with the genetic disorder tuberous sclerosis complex. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the TSC2 protein, researchers can detect and analyze its expression in various cell types, making it a versatile tool for studies in molecular biology and genetic disorders.TSC2 is a critical regulator of cell growth and proliferation, with mutations in the gene leading to the development of tumors and other manifestations of tuberous sclerosis complex.
By studying the activity of TSC2, researchers can gain insight into the molecular mechanisms underlying this disorder and potentially identify new therapeutic targets. The TSC2 Polyclonal Antibody is an essential resource for advancing our understanding of TSC2 biology and developing targeted treatments for tuberous sclerosis complex.
Product Name:
TSC2 Rabbit Polyclonal Antibody
SKU:
CAB0492
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1160-1255 of human TSC2 (NP_000539.2).
This gene is a tumor suppressor gene that encodes the growth inhibitory protein tuberin. Tuberin interacts with hamartin to form the TSC protein complex which functions in the control of cell growth. This TSC protein complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signaling which is a major regulator of anabolic cell growth. Mutations in this gene have been associated with tuberous sclerosis and lymphangioleiomyomatosis.
Purification Method:
Affinity purification
Gene ID:
7249
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from SH-SY5Y cells, using TSC2 Rabbit pAb (CAB0492) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
