The TSC1 Rabbit Monoclonal Antibody (CAB5121) is a cutting-edge tool for researchers studying the TSC1 protein, a key regulator of cell growth and proliferation. This highly specific antibody, developed using rabbit monoclonal technology, is specially designed for use in various applications such as Western blot, immunofluorescence, and immunohistochemistry.TSC1, also known as tuberous sclerosis complex 1, is a tumor suppressor gene that plays a crucial role in controlling cell size and division. Dysregulation of the TSC1 gene has been linked to the development of various cancers and genetic disorders.
By targeting the TSC1 protein, researchers can investigate its function and potential therapeutic implications in diseases such as cancer, epilepsy, and autism.With its exceptional sensitivity and specificity, the TSC1 Rabbit Monoclonal Antibody (CAB5121) offers researchers a reliable tool to explore the role of TSC1 in various biological processes. Its versatility and robust performance make it an indispensable asset for studies in oncology, neurology, and developmental biology. Unlock the potential of TSC1 research with this high-quality antibody from Assay Genie.
Product Name:
TSC1 Rabbit Monoclonal Antibody
SKU:
CAB5121
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1065-1164 of human Hamartin (Q92574).
This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signaling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including TSC2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis and lymphangioleiomyomatosis.
Purification Method:
Affinity purification
Gene ID:
7248
Clone Number:
ARC1236
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of HT-1080 cells, using TSC1 Rabbit mAb (CAB5121) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3min.
