TSC1 Rabbit Polyclonal Antibody (CAB0720)
- SKU:
- CAB0720
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | TSC1 Rabbit Polyclonal Antibody |
SKU: | CAB0720 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 600-700 of human TSC1 (NP_000359.1). |
Sequence: | QPPP YDHL FEVA LPKT AHHF VIRK TEEL LKKA KGNT EEDG VPST SPME VLDR LIQQ GADA HSKE LNKL PLPS KSVD WTHF GGSP PSDE IRTL RDQL LLLH N |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:100 IF/ICC,1:50 - 1:100 |
Synonyms: | LAM; TSC; TSC1 |
Positive Sample: | Rat spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Membrane, Peripheral membrane protein. |
Calculated MW: | 130kDa |
Observed MW: | 150kDa |
This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signaling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including TSC2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis and lymphangioleiomyomatosis.
Purification Method: | Affinity purification |
Gene ID: | 7248 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |