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PRSS2 Rabbit Polyclonal Antibody (CAB7923)

SKU:
CAB7923
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:PRSS2 Rabbit Polyclonal Antibody
SKU:CAB7923
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 24-247 of human PRSS2 (NP_002761.1).
Sequence:IVGG YICE ENSV PYQV SLNS GYHF CGGS LISE QWVV SAGH CYKS RIQV RLGE HNIE VLEG NEQF INAA KIIR HPKY NSRT LDND ILLI KLSS PAVI NSRV SAIS LPTA PPAA GTES LISG WGNT LSSG ADYP DELQ CLDA PVLS QAEC EASY PGKI TNNM FCVG FLEG GKDS CQGD SGGP VVSN GELQ GIVS WGYG CAQK NRPG VYTK VYNY VDWI KDTI AANS
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:TRY2; TRY8; TRYP2; PRSS2
Positive Sample:Mouse spleen,Mouse skeletal muscle
Conjugate:Unconjugated
Cellular Localization:Secreted, extracellular space.
Calculated MW:26kDa
Observed MW:26kDa

This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:5645
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using PRSS2 antibody (CAB7923) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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