The Trypsin-2 Polyclonal Antibody (CAB7923) is a valuable tool for researchers studying trypsin-2, a proteolytic enzyme involved in protein digestion and other physiological processes. This antibody, produced in rabbits, is highly specific to human trypsin-2 and has been validated for use in Western blot applications.Trypsin-2 is known for its role in breaking down proteins into smaller peptides and amino acids, making it essential for proper digestion and nutrient absorption. Dysregulation of trypsin-2 activity has been implicated in various digestive disorders, making it an important target for research in gastroenterology and related fields.
By using the Trypsin-2 Polyclonal Antibody, researchers can study the expression and localization of trypsin-2 in different tissues and cell types, providing valuable insights into its functions and potential implications in disease processes. This antibody is a valuable tool for investigating the role of trypsin-2 in digestive health and exploring its therapeutic potential in digestive disorders.
Product Name:
PRSS2 Rabbit Polyclonal Antibody
SKU:
CAB7923
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 24-247 of human PRSS2 (NP_002761.1).
This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5645
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PRSS2 antibody (CAB7923) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
