The TRPV6 Polyclonal Antibody (CAB16128) is a vital tool for researchers studying TRPV6, a calcium channel protein involved in various physiological processes such as calcium absorption and cellular signaling. This antibody, produced in rabbits, is highly specific to human TRPV6 and has been validated for use in Western blot applications. By specifically binding to TRPV6, researchers can detect and analyze the protein in various cell types, making it an excellent tool for investigations in calcium signaling, cancer biology, and reproductive health.
TRPV6 is a crucial player in calcium homeostasis, playing a role in regulating calcium levels in the body and influencing cell proliferation and differentiation. Dysregulation of TRPV6 has been linked to several diseases including cancer, osteoporosis, and hypertension, highlighting the importance of studying this protein in various pathological conditions. By understanding the function and regulation of TRPV6, researchers can potentially develop new therapeutic strategies targeting this calcium channel in disease treatment and management.
Product Name:
TRPV6 Rabbit Polyclonal Antibody
SKU:
CAB16128
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TRPV6 (NP_061116.5).
This gene encodes a member of a family of multipass membrane proteins that functions as calcium channels. The encoded protein contains N-terminal ankyrin repeats, which are required for channel assembly and regulation. Translation initiation for this protein occurs at a non-AUG start codon that is decoded as methionine. This gene is situated next to a closely related gene for transient receptor potential cation channel subfamily V member 5 (TRPV5). This locus has experienced positive selection in non-African populations, resulting in several non-synonymous codon differences among individuals of different genetic backgrounds.
Purification Method:
Affinity purification
Gene ID:
55503
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TRPV6 Rabbit pAb (CAB16128) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
