The TRPV5 Polyclonal Antibody (CAB6473) is a critical tool for researchers studying the TRPV5 protein, a member of the transient receptor potential (TRP) family involved in calcium transport and homeostasis. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the TRPV5 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it essential for studies in physiology, nephrology, and calcium signaling research.TRPV5 is a key player in calcium reabsorption in the kidneys, helping maintain overall calcium balance in the body.
Dysregulation of TRPV5 activity has been implicated in various disorders including kidney stones, osteoporosis, and hypercalcemia. Therefore, understanding the function and regulation of TRPV5 is crucial for developing targeted therapies to treat these conditions and maintain healthy calcium levels in the body. The TRPV5 Polyclonal Antibody provides researchers with a reliable tool to explore the role of TRPV5 in health and disease, paving the way for new treatment strategies and advancements in the field of calcium signaling research.
Product Name:
TRPV5 Rabbit Polyclonal Antibody
SKU:
CAB6473
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 655-725 of human TRPV5 (NP_062815.3).
This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.
Purification Method:
Affinity purification
Gene ID:
56302
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using TRPV5 Rabbit pAb (CAB6473) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
