Anti-TRPV3 Antibody (CAB12613)

Antibody Name:	Anti-TRPV3 Antibody
Antibody SKU:	CAB12613
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 400-500 of human TRPV3 (NP_659505.1).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:

Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 400-500 of human TRPV3 (NP_659505.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	DNSV LEIT VYNT NIDN RHEM LTLE PLHT LLHM KWKK FAKH MFFL SFCF YFFY NITL TLVS YYRP REEE AIPH PLAL THKM GWLQ LLGR MFVL IWAM CISV K
Gene ID:	162514
Uniprot:	Q8NET8
Cellular Location:	Membrane, Multi-pass membrane protein
Calculated MW:	87kDa/90kDa
Observed MW:	Refer to figures

Synonyms:

TRPV3, FNEPPK2, OLMS, VRL3

Background:

This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt Protein Function:	TRPV3: Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). May form a heteromeric channel with TRPV1. Interacts with TRPV1. Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion. Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV3 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, multi-pass; Channel, cation; Membrane protein, integral Chromosomal Location of Human Ortholog: 17p13.2 Cellular Component: plasma membrane; integral to membrane; receptor complex Molecular Function:calcium channel activity Biological Process: negative regulation of hair cycle; response to heat; transmembrane transport Disease: Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques; Palmoplantar Keratoderma, Nonepidermolytic, Focal 2
NCBI Summary:	This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
UniProt Code:	Q8NET8
NCBI GenInfo Identifier:	62901456
NCBI Gene ID:	162514
NCBI Accession:	Q8NET8.2
UniProt Secondary Accession:	Q8NET8,Q8NDW7, Q8NET9, Q8NFH2,
UniProt Related Accession:	Q8NET8
Molecular Weight:	87,661 Da
NCBI Full Name:	Transient receptor potential cation channel subfamily V member 3
NCBI Synonym Full Names:	transient receptor potential cation channel, subfamily V, member 3
NCBI Official Symbol:	TRPV3
NCBI Official Synonym Symbols:	OLMS; VRL3
NCBI Protein Information:	transient receptor potential cation channel subfamily V member 3; VRL-3; vanilloid receptor-like 3; vanilloid receptor-related osmotically activated channel protein
UniProt Protein Name:	Transient receptor potential cation channel subfamily V member 3
UniProt Synonym Protein Names:	Vanilloid receptor-like 3; VRL-3
Protein Family:	Transient receptor potential cation channel subfamily
UniProt Gene Name:	TRPV3
UniProt Entry Name:	TRPV3_HUMAN

	Immunohistochemistry of paraffin-embedded rat heart using TRPV3 antibody (CAB12613) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human prostate using TRPV3 antibody (CAB12613) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse brain using TRPV3 antibody (CAB12613) at dilution of 1:100 (40x lens).

Antibodies

Anti-TRPV3 Antibody (CAB8598)

TRPV3 Antibody (PACO01813)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)