The TRPS1 Polyclonal Antibody (CAB7743) is a valuable tool for researchers studying TRPS1, a transcription factor that plays a crucial role in skeletal development and hair follicle formation. This antibody, produced in rabbits, boasts high reactivity with human samples and has been validated for use in Western blot applications. By binding to the TRPS1 protein, this antibody allows for the detection and analysis of TRPS1 expression in various cell types.TRPS1 is known for its involvement in skeletal patterning and maintenance, making it a key player in conditions like trichorhinophalangeal syndrome.
Research on TRPS1 has also highlighted its potential role in cancer, particularly in breast and prostate tumors. By elucidating the function of TRPS1, researchers can gain insights into its impact on cell growth and differentiation, providing valuable information for potential therapeutic targets in skeletal disorders and cancers.
Product Name:
TRPS1 Rabbit Polyclonal Antibody
SKU:
CAB7743
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-260 of human TRPS1 (NP_054831.2).
This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III.
Purification Method:
Affinity purification
Gene ID:
7227
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using TRPS1 antibody (CAB7743) at 1:10000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
