The TRPM8 Rabbit Monoclonal Antibody (CAB4269) is a research tool designed for studies involving the TRPM8 protein, a member of the transient receptor potential (TRP) family of ion channels. TRPM8 is known as the cold and menthol receptor, playing a key role in detecting cold temperatures and sensations of cooling and menthol.This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting TRPM8 in human samples. Validated for use in Western blot applications, this antibody facilitates the identification and analysis of TRPM8 expression in various cell types. Its reliability and precision make it an ideal choice for research in areas such as sensory physiology, thermoregulation, and pain perception.
TRPM8 has been implicated in various physiological and pathological processes, including cold-induced pain, neurogenesis, and cancer progression. By targeting TRPM8, researchers aim to better understand its role in these processes and develop novel therapeutic strategies for conditions such as chronic pain and cancer. The TRPM8 Rabbit Monoclonal Antibody (CAB4269) provides a valuable tool for investigating the functions and mechanisms of TRPM8 in both normal and disease states.
Product Name:
TRPM8 Rabbit Monoclonal Antibody
SKU:
CAB4269
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 900-1000 of human TRPM8 (Q7Z2W7).
Predicted to enable ligand-gated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within several processes, including cellular calcium ion homeostasis; response to cold; and thermoception. Located in plasma membrane.
Purification Method:
Affinity purification
Gene ID:
79054
Clone Number:
ARC0947
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using TRPM8 Rabbit mAb (CAB4269) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
