The TRPM8 Polyclonal Antibody (CAB5333) is a valuable tool for researchers studying the TRPM8 protein, a key player in cold thermoreception and pain sensation. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it an ideal choice for Western blot applications.TRPM8, a member of the transient receptor potential (TRP) family, is known for its role in detecting and responding to cold temperatures and certain cooling compounds. Its involvement in pain signaling pathways has also garnered interest in research related to chronic pain conditions and sensory neuropathies.
By targeting the TRPM8 protein, this polyclonal antibody enables precise detection and analysis in various cell types and tissues, providing valuable insights for studies in sensory biology, pain mechanisms, and therapeutic development. Understanding the function and regulation of TRPM8 could lead to new strategies for managing pain and exploring its therapeutic potential in pain-related disorders.
Product Name:
TRPM8 Rabbit Polyclonal Antibody
SKU:
CAB5333
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 980-1104 of human TRPM8 (NP_076985.4).
Predicted to enable ligand-gated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within several processes, including cellular calcium ion homeostasis; response to cold; and thermoception. Located in plasma membrane.
Purification Method:
Affinity purification
Gene ID:
79054
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using TRPM8 Rabbit pAb (CAB5333) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
