The TRPM8 Polyclonal Antibody (CAB12572) is a valuable tool for researchers studying the TRPM8 protein, a member of the transient receptor potential (TRP) ion channel family involved in sensing cold temperatures and regulating pain sensation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.TRPM8 is primarily expressed in sensory neurons and plays a critical role in cold sensing and thermoregulation. Dysregulation of TRPM8 function has been implicated in various pain disorders, making it a promising target for the development of novel analgesic therapies.
By detecting and analyzing the TRPM8 protein in different cell types, this antibody is essential for understanding the physiological and pathological roles of TRPM8 in sensory perception and pain modulation.Researchers studying pain, sensation, and thermoregulation will benefit greatly from the use of the TRPM8 Polyclonal Antibody (CAB12572) in their experimental studies. Its specificity and reliability make it an indispensable tool for investigating the function of TRPM8 and its potential therapeutic implications in pain management.
Product Name:
TRPM8 Rabbit Polyclonal Antibody
SKU:
CAB12572
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 880-960 of human TRPM8 (NP_076985.4).
Predicted to enable ligand-gated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within several processes, including cellular calcium ion homeostasis; response to cold; and thermoception. Located in plasma membrane.
Purification Method:
Affinity purification
Gene ID:
79054
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TRPM8 Rabbit pAb (CAB12572) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
