The TRPM7 Polyclonal Antibody (CAB10075) is specifically designed for research involving TRPM7, a member of the transient receptor potential melastatin subfamily of ion channels. This antibody, generated in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By targeting the TRPM7 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for studies in ion channel physiology, cell signaling, and cancer research.TRPM7 is a unique ion channel that plays a crucial role in cell survival, proliferation, and differentiation. Dysregulation of TRPM7 has been implicated in various diseases, including cancer, cardiovascular disorders, and neurodegenerative conditions.
Understanding the function and regulation of TRPM7 is essential for developing targeted therapies that modulate ion channel activity and cell signaling pathways in these disease contexts.With its high specificity and sensitivity, the TRPM7 Polyclonal Antibody (CAB10075) is a valuable tool for researchers studying the role of TRPM7 in health and disease. Its ability to accurately detect TRPM7 protein levels in different cell types makes it a powerful asset in advancing our understanding of ion channel function and developing novel therapeutic strategies.
Product Name:
TRPM7 Rabbit Polyclonal Antibody
SKU:
CAB10075
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 756-855 of human TRPM7 (NP_060142.3).
This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function.
Purification Method:
Affinity purification
Gene ID:
54822
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of mouse skeletal muscle, using TRPM7 antibody (CAB10075) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
