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TRPM3 Antibody (PACO60396)

SKU:
PACO60396
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€359

Description

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TRPM3 Antibody (PACO60396)

The TRPM3 Polyclonal Antibody (PACO60396) is a valuable tool for researchers studying TRPM3, a member of the transient receptor potential melastatin (TRPM) family of ion channels. This antibody, produced in rabbits, is highly specific for TRPM3 and has been validated for use in various applications, including Western blotting.TRPM3 is known to play a key role in sensory signaling, particularly in processes such as nociception and thermosensation. Dysregulation of TRPM3 has been implicated in various diseases, making it a promising target for therapeutic development. By using the TRPM3 Polyclonal Antibody, researchers can effectively detect and analyze TRPM3 expression in different cell types, aiding in the advancement of research in areas such as pain management and neurological disorders.

This antibody's high reactivity with human samples and its specificity for TRPM3 make it an ideal choice for studies focused on understanding the function and regulation of TRPM3 in health and disease. Unlocking the mysteries of TRPM3 through research can potentially lead to the development of novel treatments for conditions associated with TRPM3 dysfunction.

Antibody Name:TRPM3 Antibody (PACO60396)
Antibody SKU:PACO60396
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IF
Recommended Dilutions:ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Transient receptor potential cation channel subfamily M member 3 protein (1606-1713AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunofluorescence staining of Hela cells with PACO60396 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation.
Synonyms:Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2), TRPM3, KIAA1616 LTRPC3
UniProt Protein Function:TRPM3: a transient receptor potential (TRP) ion channel. Mediates constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by calcium store depletion and muscarinic receptor activation. TRP voltage-independent calcium-permeable cation channels are divided into six subfamilies, two of which (TRPC and TRPM) have members that are widely expressed. Ten alternatively spliced isoforms have been described.Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 9q21.12-q21.13Cellular Component: integral component of membrane; plasma membraneMolecular Function: calcium activated cation channel activity; calcium channel activity; cation channel activityBiological Process: cation transport; detection of temperature stimulus; protein tetramerization; sensory perception of temperature stimulus
UniProt Protein Details:
NCBI Summary:The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:Q9HCF6
NCBI GenInfo Identifier:581985920
NCBI Gene ID:80036
NCBI Accession:AHI18585.1
UniProt Secondary Accession:Q9HCF6,Q5VW02, Q5VW03, Q5VW04, Q5W5T7, Q86SH0, Q86SH6 Q86UL0, Q86WK1, Q86WK2
UniProt Related Accession:Q9HCF6
Molecular Weight:25,159 Da
NCBI Full Name:transient receptor potential cation channel subfamily M member 3, partial
NCBI Synonym Full Names:transient receptor potential cation channel subfamily M member 3
NCBI Official Symbol:TRPM3  
NCBI Official Synonym Symbols:GON-2; MLSN2; LTRPC3  
NCBI Protein Information:transient receptor potential cation channel subfamily M member 3
UniProt Protein Name:Transient receptor potential cation channel subfamily M member 3
UniProt Synonym Protein Names:Long transient receptor potential channel 3; LTrpC-3; LTrpC3; Melastatin-2; MLSN2
Protein Family:Transient receptor potential cation channel subfamily
UniProt Gene Name:TRPM3  
UniProt Entry Name:
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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