The TRPM3 Polyclonal Antibody (PAC020765) is essential for research involving TRPM3, a calcium-permeable cation channel that plays a crucial role in various physiological processes. The antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the TRPM3 protein, this antibody allows for the detection and analysis of TRPM3 expression in different cell types, making it an ideal tool for investigations in neurobiology and pain research.TRPM3 is known for its involvement in sensory perception, such as thermal nociception and pain sensation. Its function in mediating calcium influx in response to various stimuli underscores its significance in sensory signal transduction pathways.
Research on TRPM3 is vital for understanding its role in pain processing and identifying potential therapeutic targets for pain management and neurologic disorders.The TRPM3 Polyclonal Antibody is a valuable tool for researchers seeking to explore the molecular mechanisms underlying TRPM3 activity and its implications in sensory physiology. Its application in studies related to pain modulation, sensory perception, and neurological diseases makes it a valuable asset in advancing our understanding of TRPM3 function and its potential therapeutic implications.
Antibody Name:
TRPM3 Antibody (PACO20765)
Antibody SKU:
PACO20765
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:10-1:50
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human TRPM3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20765(TRPM3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms:
transient receptor potential cation channel, subfamily M, member 3
UniProt Protein Function:
TRPM3: a transient receptor potential (TRP) ion channel. Mediates constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by calcium store depletion and muscarinic receptor activation. TRP voltage-independent calcium-permeable cation channels are divided into six subfamilies, two of which (TRPC and TRPM) have members that are widely expressed. Ten alternatively spliced isoforms have been described.Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 9q21.12-q21.13Cellular Component: integral component of membrane; plasma membraneMolecular Function: calcium activated cation channel activity; calcium channel activity; cation channel activityBiological Process: cation transport; detection of temperature stimulus; protein tetramerization; sensory perception of temperature stimulus
UniProt Protein Details:
NCBI Summary:
The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
