The TRPM2 Polyclonal Antibody (CAB6137) is specifically designed for research involving TRPM2, a calcium-permeable cation channel that plays a crucial role in various cellular processes, including inflammation and cell death. This antibody is raised in rabbits and is highly reactive with human samples, making it an ideal tool for Western blot applications.TRPM2 is known to be involved in responses to oxidative stress and is implicated in diseases such as Alzheimer's, Parkinson's, and stroke. By binding to TRPM2, this antibody enables accurate detection and analysis of the protein in different cell types, providing valuable insights for researchers studying neurobiology, neurodegenerative diseases, and inflammation.
Understanding the function of TRPM2 is essential for developing targeted therapies that can modulate its activity and potentially treat conditions associated with its dysregulation. The TRPM2 Polyclonal Antibody (CAB6137) offers a reliable tool for investigating the role of TRPM2 in health and disease, paving the way for advancements in therapeutic strategies.
Product Name:
TRPM2 Rabbit Polyclonal Antibody
SKU:
CAB6137
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1204-1503 of human TRPM2 (NP_003298.1).
The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known.
Purification Method:
Affinity purification
Gene ID:
7226
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse lung, using TRPM2 antibody (CAB6137) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
