The TRPM1 Polyclonal Antibody (CAB17509) is a valuable tool for researchers studying TRPM1, a member of the transient receptor potential (TRP) ion channel family involved in various cellular processes. This rabbit polyclonal antibody is specifically designed to target TRPM1 protein in human samples, making it an ideal choice for Western blot applications.TRPM1 is known for its role in mediating calcium influx, which is crucial for cell signaling, regulation of ion homeostasis, and sensory perception. Research on TRPM1 has shown its involvement in neurodegenerative disorders, cancer progression, and vision-related conditions.
By using this antibody, researchers can accurately detect and analyze TRPM1 expression in different cell types, providing valuable insights into its function in various physiological and pathological processes.Overall, the TRPM1 Polyclonal Antibody is a reliable and versatile tool for investigators conducting studies in neuroscience, cancer biology, and sensory physiology. Its high reactivity, sensitivity, and specificity make it a valuable asset for unraveling the complex roles of TRPM1 in health and disease.
Product Name:
TRPM1 Rabbit Polyclonal Antibody
SKU:
CAB17509
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1460-1540 of human TRPM1 (NP_002411.3).
This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4308
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of SK-MEL-28, using TRPM1 antibody (CAB17509) at 1:800 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
