The TRPC7 Polyclonal Antibody (CAB17738) is a valuable tool for researchers studying the TRPC7 protein, a member of the transient receptor potential (TRP) family involved in calcium signaling. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for Western blot applications.TRPC7 plays a key role in various cellular processes, including calcium influx, cell proliferation, and neuronal function. Dysregulation of TRPC7 has been associated with diseases such as hypertension, cardiovascular disorders, and neurodegenerative conditions.
By targeting TRPC7 with this antibody, researchers can investigate its function and potential therapeutic implications in these disease contexts.The TRPC7 Polyclonal Antibody enables precise detection and analysis of TRPC7 protein levels in a variety of cell types, providing researchers with a reliable tool for immunological and physiological studies. By understanding the role of TRPC7 in cellular signaling pathways, researchers can further elucidate its impact on disease development and progression, ultimately leading to potential therapeutic interventions.
Product Name:
TRPC7 Rabbit Polyclonal Antibody
SKU:
CAB17738
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 720-780 of human TRPC7 (NP_065122.1).
Sequence:
YLIM RIKM CLIK LCKS KAKS CEND LEMG MLNS KFKK TRYQ AGMR NSEN LTAN NTLS KPTR Y
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:2000
Synonyms:
TRP7; TRPC7
Positive Sample:
U-87MG,U-251MG,SH-SY5Y,A-549,293T,Mouse lung
Conjugate:
Unconjugated
Cellular Localization:
cis-Golgi network, nuclear envelope, perinuclear region of cytoplasm, plasma membrane
Calculated MW:
100kDa
Observed MW:
110kDa
Predicted to enable inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in metal ion transport; regulation of cytosolic calcium ion concentration; and single fertilization. Predicted to act upstream of or within calcium ion transport. Predicted to be located in plasma membrane. Predicted to be part of cation channel complex. Predicted to be integral component of plasma membrane.
Purification Method:
Affinity purification
Gene ID:
57113
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TRPC7 Rabbit pAb (CAB17738) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
