The TRPC6 Polyclonal Antibody (CAB15107) is a valuable tool for researchers studying TRPC6, a member of the transient receptor potential canonical (TRPC) family of ion channels. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.TRPC6 is a key player in various cellular functions, including calcium signaling, cell proliferation, and migration. Dysregulation of TRPC6 has been linked to diseases such as cardiovascular disorders, kidney diseases, and neurological conditions. By targeting TRPC6 with this antibody, researchers can explore the role of this ion channel in different cell types and biological processes, offering insights into potential therapeutic interventions.
With its high reactivity and specificity, the TRPC6 Polyclonal Antibody is an essential tool for investigations in the fields of physiology, pharmacology, and pathology. Its reliable performance in Western blot assays makes it a practical choice for studies seeking to understand the molecular mechanisms underlying TRPC6 function and its involvement in disease pathogenesis.
Product Name:
TRPC6 Rabbit Polyclonal Antibody
SKU:
CAB15107
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 732-931 of human TRPC6 (NP_004612.2).
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2).
Purification Method:
Affinity purification
Gene ID:
7225
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TRPC6 antibody (CAB15107) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
