The TRPC5 Polyclonal Antibody (CAB10089) is a valuable tool for researchers studying the TRPC5 protein, a member of the transient receptor potential canonical (TRPC) family that is involved in calcium signaling and ion channel regulation. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications, allowing for accurate detection of TRPC5 in various cell types.TRPC5 is known to play a role in a variety of physiological processes, including neuronal excitability, kidney function, and cardiovascular regulation. Dysregulation of TRPC5 has been implicated in several diseases, making it an attractive target for research focused on understanding and potentially targeting this protein for therapeutic purposes.
By utilizing the TRPC5 Polyclonal Antibody, researchers can further investigate the function and expression of TRPC5 in different biological contexts, ultimately leading to a greater understanding of its role in health and disease. This antibody is an essential tool for immunology, neuroscience, and cardiovascular research, providing valuable insights into the intricate mechanisms governed by the TRPC5 protein.
Product Name:
TRPC5 Rabbit Polyclonal Antibody
SKU:
CAB10089
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 800-900 of human TRPC5 (NP_036603.1).
This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1).
Purification Method:
Affinity purification
Gene ID:
7224
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using TRPC5 Rabbit pAb (CAB10089) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
