The TRPC4 Polyclonal Antibody (CAB6996) is specifically designed for researchers studying the TRPC4 protein, a member of the transient receptor potential canonical (TRPC) family which plays a critical role in calcium signaling and neuronal excitability. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.TRPC4 is known for its involvement in various physiological processes, including smooth muscle contraction, synaptic transmission, and cell proliferation. Its dysregulation has been implicated in neurological disorders, cardiovascular diseases, and cancer.
By targeting the TRPC4 protein, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially develop new therapeutic strategies.With the TRPC4 Polyclonal Antibody, scientists can accurately detect and analyze the expression of TRPC4 in different cell types, making it an essential tool for studies in neuroscience, cardiovascular biology, and cancer research. By understanding the role of TRPC4 in disease pathogenesis, researchers can work towards developing targeted interventions that improve patient outcomes.
Product Name:
TRPC4 Rabbit Polyclonal Antibody
SKU:
CAB6996
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 768-977 of human TRPC4 (NP_057263.1).
This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
7223
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TRPC4 antibody (CAB6996) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
