The TRPC1 Polyclonal Antibody (CAB12525) is a key tool for researchers studying TRPC1, a member of the transient receptor potential (TRP) superfamily known for its involvement in calcium signaling and various physiological processes. This antibody, generated in rabbits, shows high specificity for human samples and has been validated for use in Western blot applications. By binding to the TRPC1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in neuroscience, cardiovascular biology, and beyond.TRPC1 is known to play a crucial role in regulating calcium influx, which is essential for cellular functions such as neurotransmission, muscle contraction, and vascular tone.
Dysregulation of TRPC1 has been implicated in various diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer. Understanding the function of TRPC1 and its interaction with other molecules is vital for developing targeted therapies and gaining insights into disease mechanisms.Overall, the TRPC1 Polyclonal Antibody is a valuable tool for researchers seeking to unravel the complexities of calcium signaling and its impact on health and disease. Its high specificity and reliability make it an indispensable asset for investigating the role of TRPC1 in physiological and pathological processes.
Product Name:
TRPC1 Rabbit Polyclonal Antibody
SKU:
CAB12525
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human TRPC1 (NP_001238774.1).
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7220
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TRPC1 antibody (CAB12525) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
